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Genetic Laboratory Overall Design Program Guidance

Oct 15, 2018

I. General regulations

1. The construction of a scientific laboratory shall consist of experimental rooms, auxiliary rooms, and public facilities. The design should reasonably arrange all kinds of houses, so that the functional division is clear, the contact is convenient, and there is no interference.

2. The general laboratory, special laboratory and research studio should adopt the standard unit combination design. The structure selection and load determination should make the building adaptable.

3, the window

(1) Set up the scientific experiment construction of heating and air conditioning, and reduce the outer window area on the premise of meeting the lighting requirements. The external window of the laboratory with air conditioning should have good airtightness and heat insulation, and it is better to open the sash without less than 1/3 of the window area.

(2) The outer windows of the ground floor, semi-basement and basement shall be protected against insects and rodents.

4, the door

(1) The width of the doorway of a laboratory consisting of 1/2 standard units shall not be less than 1 m and the height shall not be less than 2.10 m. The width of the doorway of a laboratory consisting of one or more standard units shall not be less than 1.20m and the height shall not be less than 2.10m.

(2) The door opening size of rooms with special requirements shall be determined on a case-by-case basis.

(3) The door leaf of the laboratory shall be provided with an observation window.

(4) External doors should adopt measures to prevent insects and rodents.

5, walkway

When there is a height difference on the ground of the walkway, when the height difference is less than two steps, no steps shall be set, and the slope shall be set, and the slope shall not be greater than 1:8.

6, the stairs

(1) Stair design must comply with the current national construction design fire protection regulations.

(2) Stairs that are frequently used by scientific research personnel shall have a step width of not less than 0.28 m and a height not to be greater than 0.17 m.

(3) Elevators should be provided for the construction of scientific experiments of four or more floors.

7, the toilet

(1) The distance from the farthest working point of the toilet should not exceed 50m.

(2) The toilet should have an anteroom and be equipped with a wash basin and a mirror box.

(3) There are one toilet for every 30 people in the men's toilet. One urinal is set for every 25 people (the urinal trough is equivalent to a urinal every 0.60 m length), and the toilets and urinals should not be less than two. There are one toilet for every 15 people in the women's toilet, and it should not be less than two.

8. The sanitary equipment room should be set up in the scientific experiment construction, which can be set up independently or combined with the toilet. There should be a mop pool and mop hanging facilities and floor drains.

9, dressing room

(1) It is advisable to set up a dressing room for scientific experiment construction. The area of use should not be less than 0.60m2 per person, and there should be a locker and a shoe changer.

(2) The dressing room can be arranged in a centralized, decentralized or a combination of the two.

10, lighting

(1) General laboratory and research studio should use natural lighting, and the window area ratio of the room should not be less than 1:6.

(2) The area ratio of the reading room window using natural lighting shall not be less than 1:5.

11, sound insulation

(1) The noise level of general laboratory and academic activity room should not exceed 55dB (A sound level); the noise level of research studio and reading room should not exceed 50dB (A sound level).

(2) Utilities such as public facilities that generate noise should not be adjacent to laboratories, research studios, academic activity rooms and reading rooms. Otherwise, sound insulation and noise reduction measures should be taken.

Second, 12, vibration isolation

(1) Utilities such as public facilities that generate vibration should not be adjacent to laboratories, research studios, academic activity rooms and reading rooms, and should be located in the ground floor or underground room. Vibration isolation measures should be taken for the equipment foundation.

(2) Air-conditioning machine rooms, exhaust fan rooms, etc., which are located on the floor or the top floor, and the equipment foundation should be subjected to vibration isolation measures.

13, indoor net height

(1) Indoor net height of general laboratory and research studio: When air conditioning is not set, it should not be lower than 2.80m; when setting air conditioning, it should not be lower than 2.40m.

(2) The indoor net height of the special laboratory shall be determined according to the requirements of the size, installation and maintenance of the experimental equipment.

(3) The net height of the aisle should not be lower than 2.20m.

14, interior decoration

(1) The floor of the experimental room, the walkway and the stair surface shall be solid, wear-resistant, waterproof, non-slip, dust-free, and dust-free; the wall shall be smooth, glare-free, moisture-proof, dust-free, and dust-free; Should be smooth, no glare, no dust, no dust.

(2) The laboratory ground using strong acid and alkali should have acid and alkali corrosion resistance; the ground of the laboratory with more water should be ground drain.

(3) Laboratories that require regular cleaning, disinfection or dust-proof requirements should have an integrated waterproof finish on the floor, wall and ceiling. Between the wall and the wall, between the wall and the ground, between the wall and the ceiling should be made into a half round with a radius of not less than 0.05m. Indoors should reduce outstanding construction fittings and exposed pipes.

(4) The general laboratory should not be equipped with a ceiling.

(5) For the space where the ceiling is required and there is no strict sealing requirement, the movable plate type ceiling should be adopted.

lab furniture 10.11

Second, the general laboratory

1. The general laboratory standard unit combination design should meet the requirements for use, and be closely integrated with the layout of the fume hood, the test bench and the experimental equipment, the structure selection and the space layout of the pipeline.

2. The standard laboratory unit opening should be determined by the width, arrangement and spacing of the test bench. The standard unit arranged in parallel on the test bench should not be less than 6.60m.

3. The depth of the standard laboratory unit should be determined by the length of the test bench, the fume hood and the equipment of the experimental equipment, and should not be less than 6.60m; when there is no fume hood, it should not be less than 5.70m.

4. For general-purpose laboratories consisting of 1/2 standard units, the clearance between the side experimental benches placed on the side walls should not be less than 1.60m. When the side wall is replaced by a fume hood or laboratory equipment, the clearance between it and the other side of the test bench should not be less than 1.50m.

5. A general laboratory consisting of a standard unit, the clearance between the side experimental benches arranged on the side walls and the island or peninsula central test bench arranged in the middle of the room shall not be less than 1.60 m. When the ventilating cabinet or laboratory equipment is replaced by the side wall or the middle of the room, the clear distance between the ventilating cabinet and the experimental equipment should not be less than 1.50m. The clearance between the end of the island bench and the outer wall should not be less than 6.60m.

6. If the side wall or the side walls are close to the outer wall and open the door to other spaces, the corresponding clearance should be increased by 0.10m.

7. A general-purpose laboratory consisting of more than one standard unit. When two or more island-type test stands are arranged continuously, the clearance between the end and the outer wall should not be less than 1 m.

8. The island or peninsula central experimental platform should not be arranged in parallel with the outer window. When it must be arranged in parallel with the outer window, the clearance between it and the outer wall should not be less than 1.30m.

9. It is not advisable to place the experimental bench on the side wall with the window. It should not be placed on the side of the window to arrange the side experimental bench that needs the supply of public facilities.

10. The clearance between the end of the side experimental bench and the walkway wall, which is arranged by the side wall, should not be less than 1.20m. The clearance between the end of the central test bench and the walkway wall shall not be less than 1.20 m. When the laboratory sets the door bucket that retreats into the room, the clearance between the end of the test bench and the wall that retreats into the door should not be less than 1.20 m.

11. When the operating surface of the fume hood is opposite to the end of the test bench, the clearance between them should not be less than 1.20m.

12. The general laboratory should consist of one or more standard units.

13. The general laboratory should be concentrated on the exterior wall of the building. A general laboratory for setting air conditioning should be placed in the north.

Third, the special laboratory

1. For special laboratories consisting of standard units, the opening and depth of the laboratory shall be determined according to the requirements of the dimensions of the laboratory equipment, installation and maintenance.

2. For the special laboratory with temperature and humidity control requirements, the corresponding technical measures should be taken for the construction design.

3. Biological culture room

4. The biological culture room consists of the anterior chamber, the preparation room, the biological culture room, the instrument disinfection and the cleaning room. The use area of the front room should not be less than 8m2, and the front room should be equipped with a wardrobe and a shoe changer that separate the family clothes and work clothes.

5. A biological culture area consisting of several biological culture rooms, or a centralized dressing change shoe cabinet at the entrance.

6. The biological culture room should prevent cross-infection of human flow. It should be placed at the end of the building, and it is not appropriate to open an external window. When there is an outer window, it should be double-layered closed window and blackout louver.

7. A solid brick wall should be set between the biological culture room or the biological culture area and the abiotic culture area. The functional rooms of the biological culture room should be separated by a sealed glass partition wall. The skeleton of the glass partition wall should be made of materials that are not easily deformed and washable.

8. The door of the biological culture room and the glass partition wall of each functional room should adopt sliding doors.

9. The biological culture room should have a position where the sterilizer is set.

10, balance room

(1) The balance chamber should be provided with an anterior chamber with an area of not less than 6 m2, and can also be used as a dressing and changing room. The balance room should be arranged in the north direction, and the outer window should be double-layered with closed windows and curtains.

(2) The balance between the balance chamber and the front chamber shall be separated by a sealed glass partition wall, and sliding doors shall be used.

(3) The platform platform and pedestal of the platform shall be treated with vibration isolation. When the platform is arranged along the wall, it should be separated from the wall. The countertop should be flat, smooth, and rigid enough, and no wooden workbench should be used. The platform base on the floor should be located in a rigid area such as a wall and beams.

(4) In addition to meeting the requirements of the above-mentioned balance chamber, the high-precision balance chamber should be arranged in the north direction of the bottom floor of the experimental building. The platform base should be provided with a separate base (not to be placed above the basement floor). The outer window should be double-sealed.

(5) The permissible vibration limit of the independent base of the high-precision balance chamber shall be selected according to the data provided by the manufacturing department. If there is no data, it shall comply with the current vibration calculation and separation of the load-bearing structure of the building under the dynamic load of the machine. Regulations for Vibration Design Regulations.

11, electron microscope room

(1) The electron microscope chamber shall be arranged away from the vibration source and the magnetic field interference source according to the permissible vibration speed and anti-magnetic requirements of the equipment used, and shall be arranged on the bottom layer of the building.

(2) The electron microscope room consists of an electron microscope, a transition room, a preparation room, a section, a film, and a dark room. The transition area should not be less than 6m2, and there should be a locker and a shoe changer.

(3) It is not advisable to have an external window between the electron microscopes.

(4) The indoor clear height between the electron microscopes shall be determined according to the equipment height and maintenance requirements.

(5) The electromagnetic mirror base should adopt vibration isolation measures. Vibration isolation equipment and indoor air conditioning equipment used in conjunction with the electron microscope shall be provided with vibration isolation devices.

(6) The air between the electron microscope, the section and the coating film should be filtered. Personnel entrances and exits must have lockers and shoe lockers.

12, spectrometer analysis room

(1) The spectrometer analysis chamber should be arranged away from the vibration source and should be placed on the bottom of the building. When it is necessary to be placed on the floor, appropriate vibration isolation measures should be taken.

(2) Spectrometer analysis room consists of spectrometer, transition, sample preparation room, chemical treatment room, dark room, data processing room and working room. The transition area should not be less than 6m2, and there should be a locker and a shoe changer.

(3) The fume hood should be set according to the requirements of use. An air hood should be provided in the light source area.

(4) It is not advisable to have a water basin in the spectrometer.

13. Radioisotope laboratory

(1) The provisions of this Section apply to the construction design of Class III open-type radioactive work units for scientific research and Class B and C open-type radioisotope laboratories and sealed radioactive source irradiation laboratories belonging to the second type of radiological medical units.

(2) Open radioisotope laboratory

1 Open-type radioactive work units are classified into three categories according to the equivalent annual usage of the radionuclides used, namely, the first, second and third categories. The equivalent annual consumption of various types of work units shall comply with the current "Basic Standards for Radiation Health Protection".

2 Open radioisotope laboratories (or workplaces) are classified into three grades according to the maximum equivalent enthalpy of operation of the radionuclides used, namely grades A, B and C. The maximum equivalent operating capacity of the laboratory (or workplace) at all levels shall be in accordance with the current Radiation Protection Regulations.

3 Open-type radiation work units shall be marked with a protection monitoring area around them according to their category. The scope of the protective monitoring area shall comply with the current "Basic Standards for Radiation Health Protection".

4 The third type of open-type radiation work units and the radiation medical units belonging to the second category may be located in urban areas.

5 Class III open-type radiation work units and Class B and C radioisotope laboratories (or workplaces) belonging to the second type of radiological medical units may be located in general buildings, but should be concentrated on the same floor or at one end, and Non-radiative workplaces are separated.

6 When the radioisotope laboratory (or workplace) is arranged, it should be divided into several areas according to the pollution situation: Class B radioisotope laboratory (or workplace) can be divided into three areas, namely, white area, green area and Red area. The Class C radioisotope laboratory (or workplace) can be divided into two zones, namely the white zone and the green zone. When the maximum equivalent 曰 operation is less than the lower limit specified by the Class C laboratory (or workplace), it may not be partitioned. The standards for the White Zone, Green Zone and Red Zone shall comply with the current “Design Specification for Radiation Protection of Open Radioactive Materials Laboratory”.

7 The layout of each area of the Class B radioisotope laboratory (or workplace) shall be arranged according to the blush area of the green area of the Bai District. Class C radioisotope laboratories (or workplaces) should be arranged in the green area of the White Area. There should be a sanitary entrance between the white area and the green area of the Class B laboratory (or workplace). Household clothes closets, special work clothes closets and showers shall be provided in the sanitary entrances and exits, together with surface pollution monitoring instruments. Between the white area and the green area of the Class C laboratory (or workplace), there should be transition rooms for shoe change, dressing, hand washing and surface contamination monitoring. The transition area should not be less than 6 m2. The size of the health entrances and exits should be determined based on the total number of people entering the green area. The shower is set for every 5 to 8 people according to the maximum number of students.

8 The arrangement of the radioisotope laboratory, the white area and the white area, the green area and the green area should be relatively concentrated to avoid interpenetrating. The arrangement of the radioisotope laboratory is, in principle, arranged in order of low, medium and high radioactivity.

9 The green area of the radioisotope laboratory shall be provided with a temporary storage of radioactive solid waste. The standard of interior decoration in the temporary storage room should not be lower than that of the radioisotope laboratory.

The indoor decoration of 10 radioisotope laboratories (or workplaces) should be simple and should prevent dust accumulation and accumulation of radioactive materials. All kinds of pipelines should be darkly coated, and the lamps should be embedded. The corners of the ground, wall and ceiling should be made into half rounds with a radius of not less than 0.05m.

• Doors and windows in radioisotope laboratories (or workplaces) should be easy to clean and decontaminate. The green area should be provided with a closed window, and there should be no opening sash.

The indoor decoration materials of the Class B radioisotope laboratory (or workplace) should have a smooth surface, poor adsorption to radioactive materials, easy decontamination, and good acid, alkali corrosion and radiation resistance. It is advisable to use PVC plastic coil monolithic floor and skirting board. The joints should be welded by heat, and the height of the skirting board should not be lower than 0.25m. Walls and ceilings should be painted.

• The indoor decoration standards for Class C radioisotope laboratories (or workplaces) may be appropriately reduced. The existing terrazzo floor can be used, but it must be waxed and partially covered with plastic. Painted walls and a dust-free paint roof can be used.

The process design, ventilation design, water supply and drainage design, radiation shielding design, radiation monitoring design and radioactive three-waste treatment of the open-type radioisotope laboratory shall meet the requirements of the current “Design Specification for Radiation Protection of Open Radioactive Materials Laboratory”.

(3) Sealed radioactive source irradiation laboratory

1 The design requirements for the sealed radioactive source irradiation laboratory can be implemented in accordance with the current “Design Specification for Radiation Safety Protection of 60Co Irradiation Station”.

2 sealed radioactive source irradiation laboratory can be located in urban areas. Irradiation devices in the laboratory shall be provided with effective shielding measures and shall be such that the exposure to the surrounding public does not exceed the corresponding dose equivalent limits of the current Radiation Protection Regulations.

3 The sealing wall, ceiling and door, observation window opening, etc. of the sealed radioactive source irradiation laboratory shall meet the protection requirements. The radiation safety protection design of the 60Co irradiation station shall comply with the current "Design Specification for Radiation Safety Protection of 60Co Irradiation Station".

4 The storage room of the sealed radioactive source must meet the protection requirements to ensure the safety of the surrounding environment. The storage pit of the storage source container shall be protected from groundwater infiltration and shall be kept dry. The storage room should be equipped with fire prevention, anti-theft and alarm devices.

Fourth, research studio, academic activity room, library room

1. Research studio

(1) The number of research studios should be determined according to the requirements of use, and the area used per person should not be less than 6m2.

(2) The research studio should be placed close to the laboratory or combined with the laboratory.

2. Academic activity room

(1) The area of use of the academic exchange exhibition hall shall be determined according to the requirements for use. The site should be connected to public transportation spaces and should have space for seating or sofas.

(2) The use area of small academic activity room should not be less than 40m2; the use area of medium-sized academic activity room should not be less than 60m2. The area used by each of the small and medium-sized academic activity rooms: there should be no less than 1.80 m2 for conference tables and no less than 0.80 m2 for conference rooms.

(3) The size of the academic lecture hall shall be determined according to the requirements of use, and it is advisable to have a podium, a writing board, a curtain, and a space for placing projection equipment. When the number of people in the room exceeds 180, the stepped floor should be adopted, and the height of the step should be determined according to the requirement of not obstructing the line of sight. A fixed seat and a recording board should be provided. When the seat comes with a recording platen, the row spacing should not be less than 0.95m; when a stand-alone recording table is set, the row spacing should not be less than 1m.

3. Library and Reference Room

(1) The library should consist of a collection part, an editing part, a reading part, a cashier and a catalogue.

(2) The library should be placed in a quiet place and in a convenient location for contact with the experimental room.

(3) The library room should use an open reading room.

5. Public facilities and pipeline space

1, public facilities

(1) Utilities housing includes refrigerator room, air-conditioning room, exhaust fan room, water supply and drainage and water treatment room, power distribution room, telecommunications room, gas supply room, etc.

(2) The utility room should be arranged close to the corresponding use load center.

(3) When the public facilities are arranged in the basement, measures such as moisture, water and ventilation should be taken.

2, pipe space

(1) The pipeline space is divided into three types: pipeline wells, pipeline corridors and pipeline technology layers. The size and location shall be determined according to the requirements of construction standard unit combination design, utility system design, installation and maintenance.

(2) Pipeline wells should be used when there are not many pipes in the building. Centralized pipeline wells shall be provided with inspection doors; when decentralized pipeline wells are difficult to install and repair doors, inspection and repair ports shall be provided at the pipeline valves.

(3) When there are many pipes in the building and the pipeline wells cannot meet the requirements, the pipeline corridor or the technical layer of the pipeline shall be provided, and the inspection doors shall be provided.

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